Description

8-Bromo-1,6-naphthyridine-2-carboxylic acid is a high-value, functionalized heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique bromine and carboxylic acid moieties enable precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used to develop new herbicides, fungicides, and insecticides with novel modes of action.
• Ligand Synthesis: Serves as a building block for creating complex ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into organic semiconductors, light-emitting materials, and other functional polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship (SAR) exploration by allowing derivatization at multiple reactive sites.

Basic Information

Product Name	8-Bromo-1,6-naphthyridine-2-carboxylic Acid
CAS No.	197507-55-4
Molecular Formula	C9H5BrN2O2
Molecular Weight	253.05 g/mol
Synonyms	8-Bromo-1,6-naphthyridine-2-carboxylic acid; 2-Carboxy-8-bromo-1,6-naphthyridine; 8-Bromo-1,6-naphthyridine-2-carboxylate; 197507-55-4; 8-Bromo-1,6-naphthyridine-2-carboxylic acid (CAS 197507-55-4); 8-Bromo-1,6-naphthyridine-2-carboxylic acid, 97%; 8-Bromo-1,6-naphthyridine-2-carboxylic acid, 95%
EINECS	Contact for details

Quality Control

Our 8-Bromo-1,6-naphthyridine-2-carboxylic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.