Description

(R)-2-Amino-3-Pyridin-3-Yl-Propionic Acid Methyl Ester 2 Hcl is a chiral, non-natural amino acid derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in the areas of enzyme inhibitors and receptor modulators. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers requiring high-purity, enantiomerically pure intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, kinase inhibitors, and other targeted therapeutics.
• Peptidomimetics Research: Used to incorporate a pyridylalanine moiety into peptide backbones to enhance binding affinity and metabolic stability.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric transformations to construct complex molecular architectures.
• Agrochemical Development: Potential use in creating chiral active ingredients for crop protection agents.

Basic Information

Product Name	(R)-2-Amino-3-Pyridin-3-Yl-Propionic Acid Methyl Ester 2 Hcl
CAS No.	197088-84-9
Molecular Formula	C10H15Cl2N2O2
Molecular Weight	266.15 g/mol
Synonyms	(R)-3-Pyridylalanine Methyl Ester Dihydrochloride; (R)-Methyl 2-amino-3-(3-pyridyl)propanoate hydrochloride; (R)-β-3-Pyridylalanine Methyl Ester Hydrochloride; (R)-2-Amino-3-(3-pyridinyl)propanoic Acid Methyl Ester Hydrochloride; (R)-3-(3-Pyridyl)-L-alanine Methyl Ester 2HCl; Methyl (R)-2-amino-3-(pyridin-3-yl)propanoate dihydrochloride; (R)-H-Phe(3-Pyridyl)-OMe · 2HCl
EINECS	Contact for details

Quality Control

Our production of (R)-2-Amino-3-Pyridin-3-Yl-Propionic Acid Methyl Ester 2 Hcl adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Each batch is characterized by advanced analytical techniques including HPLC, chiral analysis, and NMR to ensure identity, purity, and enantiomeric excess. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.