Description

Methyl 2-Chloro-4-(Trifluoromethyl)Nicotinate is a high-value fluorinated pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in its trifluoromethyl and chloro substituents, which are strategically positioned to enable the construction of complex molecules with enhanced biological activity and physicochemical properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science Research: Serves as a precursor for the development of specialty chemicals, liquid crystals, and functional materials requiring fluorinated aromatic systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.
• Academic & Industrial R&D: Utilized in laboratories for method development, exploring new chemical reactions, and creating compound libraries for screening.

Basic Information

Item	Details
Product Name	Methyl 2-Chloro-4-(Trifluoromethyl)Nicotinate
CAS No.	196708-48-2
Molecular Formula	C8H5ClF3NO2
Molecular Weight	239.58 g/mol
Synonyms	2-Chloro-4-(trifluoromethyl)nicotinic acid methyl ester; Methyl 2-chloro-4-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-chloro-4-(trifluoromethyl)-, methyl ester; 196708-48-2; Methyl 2-chloro-4-trifluoromethylnicotinate
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Chloro-4-(Trifluoromethyl)Nicotinate adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability. All materials are subjected to rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.