Description

Methyl (2S,4R)-1-(tert-Butoxycarbonyl)-4-Methylpyroglutamate CAS NO 196394-49-7 is a high-purity, stereochemically defined chiral building block and advanced pharmaceutical intermediate. This compound is critical for ensuring the precise stereochemistry required in the synthesis of complex bioactive molecules, particularly peptides and peptidomimetics. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including protease inhibitors and other specialized drug candidates.

Application

• Key Intermediate in Peptide Synthesis: Serves as a crucial building block for introducing the (2S,4R)-4-methylproline or related constrained amino acid motifs into peptide chains.
• Pharmaceutical R&D: Used in the research and development of novel drug candidates, particularly those targeting proteases like HCV NS3/4A and other enzymes.
• Synthesis of Bioactive Molecules: Employed in constructing the core structures of peptidomimetics and macrocyclic compounds with potential therapeutic activity.
• Process Chemistry & Scale-up: Provides a defined chiral starting point for the scalable synthesis of Active Pharmaceutical Ingredients (APIs) under current Good Manufacturing Practice (cGMP) guidelines.
• Academic Research: Utilized in synthetic organic chemistry studies focused on stereoselective synthesis and methodology development.
• Custom Synthesis: Acts as a foundational substrate for the custom synthesis of more complex, target-specific molecules for client projects.

Basic Information

Product Name	Methyl (2S,4R)-1-(tert-Butoxycarbonyl)-4-Methylpyroglutamate
CAS No.	196394-49-7
Molecular Formula	C12H19NO5
Molecular Weight	257.28 g/mol
Synonyms	(2S,4R)-1-[(tert-Butoxy)carbonyl]-4-methyl-5-oxopyrrolidine-2-carboxylic acid methyl ester; Methyl (2S,4R)-1-Boc-4-methyl-5-oxopyrrolidine-2-carboxylate; (2S,4R)-1-Boc-4-methylpyroglutamic acid methyl ester; (2S,4R)-4-Methyl-1-Boc-pyroglutamic acid methyl ester; (2S,4R)-1-(tert-Butoxycarbonyl)-4-methyl-2-pyrrolidone-5-carboxylic acid methyl ester; (2S,4R)-Boc-4-Me-Pro-OMe (pyroglutamate form); (2S,4R)-1-Boc-4-methyl-2,5-pyrrolidinedione-2-carboxylate methyl ester; (2S,4R)-4-Methyl-1-(Boc)-D-proline methyl ester (lactam)
EINECS	Contact for details

Quality Control

Our Methyl (2S,4R)-1-(tert-Butoxycarbonyl)-4-Methylpyroglutamate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.