Description

Trimethyl(2-(2-(Tetrahydro-2H-Pyran-2-Yloxy)Phenyl)Ethynyl)Silane (Wx686802) is a specialized organosilicon building block featuring a silyl-protected alkyne and a tetrahydropyranyl (THP) ether protecting group. This compound is valued for its dual-protected functionality, which provides orthogonal reactivity for sophisticated multi-step synthetic sequences. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring alkyne coupling or click chemistry strategies.
• Organic Synthesis Reagent: Used in Sonogashira coupling, Huisgen cycloaddition, and other palladium-catalyzed cross-coupling reactions to introduce arylacetylene moieties.
• Ligand & Catalyst Development: Serves as a precursor for creating novel ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and other functional materials where conjugated systems are critical.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and bioconjugates for imaging, diagnostics, and proteomics studies.
• Academic & Industrial R&D: A versatile reagent for methodological development and exploring new synthetic pathways in laboratory settings.

Basic Information

Product Name	Trimethyl(2-(2-(Tetrahydro-2H-Pyran-2-Yloxy)Phenyl)Ethynyl)Silane (Wx686802)
CAS No.	196106-30-6
Molecular Formula	C₁₈H₂₆O₂Si
Molecular Weight	302.48 g/mol
Synonyms	2-[(2-Trimethylsilylethynyl)phenoxy]tetrahydro-2H-pyran; 2-(2-(Tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyltrimethylsilane; 1-(Tetrahydro-2H-pyran-2-yloxy)-2-[(trimethylsilyl)ethynyl]benzene; THP-Protected 2-(Trimethylsilylethynyl)phenol; WX-686802; Silane, trimethyl[2-[2-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethynyl]-
EINECS	Contact for details

Quality Control

Our Trimethyl(2-(2-(Tetrahydro-2H-Pyran-2-Yloxy)Phenyl)Ethynyl)Silane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.