Description

1,2-Pyrrolidinedicarboxylic Acid, 5-Hydroxy-, 1-(1,1-Dimethylethyl) 2-Ethyl Ester, (2S)- is a high-purity, chiral pyrrolidine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its stereochemical integrity and functional group versatility, enabling the construction of complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides for enhanced efficacy and environmental safety.
• Catalyst and Ligand Development: Serves as a precursor for novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: The pyrrolidine core structure makes it valuable for designing and synthesizing peptide analogs and conformationally restricted bioactive molecules.
• Academic & Industrial R&D: A versatile reagent for methodological studies in organic chemistry and process development in fine chemical manufacturing.

Basic Information

Product Name	1,2-Pyrrolidinedicarboxylic Acid, 5-Hydroxy-, 1-(1,1-Dimethylethyl) 2-Ethyl Ester, (2S)-
CAS No.	194594-23-5
Molecular Formula	C13H23NO5
Molecular Weight	273.33 g/mol
Synonyms	(2S)-5-Hydroxy-1-(tert-butyl) 2-ethyl pyrrolidine-1,2-dicarboxylate; 1-(tert-Butyl) 2-ethyl (2S)-5-hydroxypyrrolidine-1,2-dicarboxylate; (S)-1-(tert-Butoxycarbonyl)-5-hydroxy-2-pyrrolidinecarboxylic acid ethyl ester; (S)-1-Boc-5-hydroxyproline ethyl ester; (S)-Ethyl 5-hydroxy-1-((tert-butoxy)carbonyl)pyrrolidine-2-carboxylate; (2S)-1-tert-Butyl 2-ethyl 5-hydroxypyrrolidine-1,2-dicarboxylate; 5-Hydroxy-L-proline-1-Boc-2-ethyl ester; L-Proline derivative, 5-hydroxy-, 1-Boc, 2-OEt
EINECS	Contact for details

Quality Control

Our 1,2-Pyrrolidinedicarboxylic Acid, 5-Hydroxy-, 1-(1,1-Dimethylethyl) 2-Ethyl Ester, (2S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.