Description

1(2H)-Pyridinecarboxylic Acid, 3-(Chloromethyl)-5,6-Dihydro-, Methyl Ester is a specialized heterocyclic building block featuring a fused pyridine-dihydro structure with a reactive chloromethyl group. This compound matters for its dual functionality, serving as a key synthon in the synthesis of complex pharmacologically active molecules and advanced agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel nitrogen-containing scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging its heterocyclic core.
• Chemical Research & Development: Serves as a versatile precursor for creating complex heterocyclic libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal catalysis and organocatalysts due to its nitrogen-containing structure.
• Material Science Precursor: Potential use in the synthesis of functionalized polymers or organic electronic materials.

Basic Information

Product Name	1(2H)-Pyridinecarboxylic Acid, 3-(Chloromethyl)-5,6-Dihydro-, Methyl Ester
CAS No.	194492-02-9
Molecular Formula	C8H10ClNO2
Molecular Weight	187.62 g/mol
Synonyms	3-(Chloromethyl)-5,6-dihydro-1(2H)-pyridinecarboxylic acid methyl ester; Methyl 3-(chloromethyl)-5,6-dihydro-2H-pyridine-1-carboxylate; 3-Chloromethyl-5,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester; 1-Carbomethoxy-3-chloromethyl-1,2,3,6-tetrahydropyridine; 3-(Chloromethyl)-1,2,3,6-tetrahydropyridine-1-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1(2H)-Pyridinecarboxylic Acid, 3-(Chloromethyl)-5,6-Dihydro-, Methyl Ester is produced under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.