Description

(R)-2-(4-Fluorophenyl)-3-[4-(Phenylmethoxy)Phenyl]-2-Azaspiro[3.5]Nonane-1,7-Dione is a high-purity, chiral spirocyclic compound of significant interest in advanced organic synthesis. This compound serves as a sophisticated key intermediate and building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily required by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly those targeting central nervous system (CNS) disorders and other specialized applications.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the research and synthesis of novel drug candidates, especially for CNS-targeted therapies.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex spirocyclic molecular architectures.
• Asymmetric Catalysis Studies: Serves as a substrate or ligand precursor in the development of new catalytic systems.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Medicinal Chemistry: Integral for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.

Basic Information

Item	Details
Product Name	(R)-2-(4-Fluorophenyl)-3-[4-(Phenylmethoxy)Phenyl]-2-Azaspiro[3.5]Nonane-1,7-Dione
CAS No.	194367-70-9
Molecular Formula	C31H28FNO3
Molecular Weight	481.56 g/mol
Synonyms	(R)-2-(4-Fluorophenyl)-3-[4-(benzyloxy)phenyl]-2-azaspiro[3.5]nonane-1,7-dione; (R)-2-(p-Fluorophenyl)-3-[4-(benzyloxy)phenyl]-2-azaspiro[3.5]nonane-1,7-dione; 2-Azaspiro[3.5]nonane-1,7-dione, 2-(4-fluorophenyl)-3-[4-(phenylmethoxy)phenyl]-, (2R)-; UNII-1J3Q0F4S8Q; 1J3Q0F4S8Q; (2R)-2-(4-Fluorophenyl)-3-[4-(phenylmethoxy)phenyl]-2-azaspiro[3.5]nonane-1,7-dione
EINECS	Contact for details

Quality Control

Our (R)-2-(4-Fluorophenyl)-3-[4-(Phenylmethoxy)Phenyl]-2-Azaspiro[3.5]Nonane-1,7-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric excess, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.