Description

4-(2,4-Difluoro-Phenyl)-3-Oxo-Butyric Acid Ethyl Ester is a high-purity, versatile β-keto ester building block characterized by its difluorinated aromatic ring. This compound is essential for its role as a key synthetic intermediate in the development of complex, biologically active molecules. It is primarily sought after by research and development teams and production chemists in the pharmaceutical and agrochemical industries for constructing advanced chemical scaffolds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluorophenyl moiety contributes to enhanced biological activity and metabolic stability.
• Chemical Research & Development: Serves as a versatile building block for organic synthesis, enabling Claisen condensations, Michael additions, and the formation of heterocyclic compounds.
• Material Science Precursor: Potential use in the development of specialty polymers and advanced organic materials with specific electronic or optical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.

Basic Information

Product Name	4-(2,4-Difluoro-Phenyl)-3-Oxo-Butyric Acid Ethyl Ester
CAS No.	194240-96-5
Molecular Formula	C12H12F2O3
Molecular Weight	242.22 g/mol
Synonyms	Ethyl 4-(2,4-difluorophenyl)-3-oxobutanoate; 3-Oxobutanoic acid, 4-(2,4-difluorophenyl)-, ethyl ester; Ethyl 2,4-difluoro-β-oxobenzenebutanoate; 4-(2,4-Difluorophenyl)-3-oxobutyric acid ethyl ester; 2,4-DFP-OBEE; Ethyl (2,4-difluorobenzoyl)acetate; Butyric acid, 4-(2,4-difluorophenyl)-3-oxo-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of 4-(2,4-Difluoro-Phenyl)-3-Oxo-Butyric Acid Ethyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to support cGMP compliance for pharmaceutical applications, and we can accommodate specific customer testing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.