Description

trans-3-(tert-Butyldimethylsilyloxy)-N is a high-purity, protected intermediate of significant value in advanced organic synthesis. Its core value proposition lies in its role as a versatile building block for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the life sciences sector who require reliable, high-quality intermediates for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in the synthesis of modified peptides where the tert-butyldimethylsilyl (TBDMS) group protects sensitive hydroxyl functionalities.
• Natural Product Synthesis: Serves as a crucial intermediate in the total synthesis of complex natural products with biological activity.
• Agrochemical Research: Employed in the development of new agrochemicals and plant protection agents.
• Material Science: Potential use as a precursor for specialty polymers or functionalized materials requiring specific silicon-containing motifs.
• Academic & Contract Research: A valuable reagent for methodology development and exploratory chemistry in academic and industrial R&D laboratories.

Basic Information

Product Name	trans-3-(tert-Butyldimethylsilyloxy)-N
CAS No.	194233-66-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	trans-3-(tert-Butyldimethylsilyloxy)-N; 194233-66-4; (3R,5S)-3-[(tert-Butyldimethylsilyl)oxy]-1-azabicyclo[3.2.0]heptan-7-one (related structure); TBDMS-protected lactam intermediate; tert-Butyldimethylsilyl ether lactam; Protected β-lactam intermediate; Silicon-protected bicyclic intermediate
EINECS	Contact for details

Quality Control

Every batch of trans-3-(tert-Butyldimethylsilyloxy)-N is produced and tested under a strict quality management system to ensure consistency and reliability for your critical synthesis workflows. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards for high-purity intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.