Description

n-Boc-trans-4-Cyano-L-Proline Methyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide mimetics and enzyme inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce a constrained proline analog with a functionalizable cyano group.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore novel bioactive compounds and drug candidates.
• Chemical Biology Probes: Acts as a building block for creating labeled or tagged molecules used to study biological processes and protein interactions.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.

Basic Information

Product Name	n-Boc-trans-4-Cyano-L-Proline Methyl Ester
CAS No.	194163-91-2
Molecular Formula	C13H20N2O4
Molecular Weight	268.31 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-cyano-L-proline methyl ester; (2S,4R)-1-[(tert-Butoxy)carbonyl]-4-cyanopyrrolidine-2-carboxylic acid methyl ester; Methyl (2S,4R)-1-[(tert-butoxy)carbonyl]-4-cyanopyrrolidine-2-carboxylate; trans-4-Cyano-L-proline methyl ester N-Boc derivative; Boc-4-CN-L-Pro-OMe; Boc-trans-4-cyano-L-proline methyl ester; trans-L-4-Cyanoproline methyl ester N-Boc protected
EINECS	Contact for details

Quality Control

Our n-Boc-trans-4-Cyano-L-Proline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.