Description

1H-Pyrazole-5-Carboxylic Acid, 4,5-Dihydro-, Methyl Ester, (R)- (9Ci) is a high-purity chiral building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules with specific stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce the (R)-configured dihydropyrazole moiety into their target structures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in kinase inhibitor and other targeted therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where specific chirality enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multistep synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic chemistry and process chemistry optimization.

Basic Information

Item	Details
Product Name	1H-Pyrazole-5-Carboxylic Acid, 4,5-Dihydro-, Methyl Ester, (R)- (9Ci)
CAS No.	193945-98-1
Molecular Formula	C5H8N2O2
Molecular Weight	128.13 g/mol
Synonyms	(R)-4,5-Dihydro-1H-pyrazole-5-carboxylic acid methyl ester; Methyl (R)-4,5-dihydro-1H-pyrazole-5-carboxylate; (R)-Methyl 4,5-dihydro-1H-pyrazole-5-carboxylate; (R)-1,2-Dihydropyrazole-3-carboxylic acid methyl ester; (R)-DHP-ester; (R)-DHP-Carboxylic Acid Methyl Ester; (R)-Pyrazoline-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole-5-Carboxylic Acid, 4,5-Dihydro-, Methyl Ester, (R)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.