Description

5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine, 3,10-Dibromo-8-Chloro-6,11-Dihydro-11-(4-Piperidinyl)-, (11R)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value for its role as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise stereochemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of next-generation small molecule drugs, where its specific stereoconfiguration and functional groups are critical for biological activity.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Synthesis of Biologically Active Molecules: Serves as a core scaffold for constructing compounds with potential activity in central nervous system (CNS), anti-inflammatory, or oncological targets.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs for custom synthesis projects requiring high-fidelity chiral intermediates.
• Academic Research: Utilized in universities and research institutes for studying novel organic synthesis methodologies and heterocyclic chemistry.

Basic Information

Product Name	5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine, 3,10-Dibromo-8-Chloro-6,11-Dihydro-11-(4-Piperidinyl)-, (11R)-
CAS No.	193276-49-2
Molecular Formula	C21H21Br2ClN2
Molecular Weight	496.67 g/mol
Synonyms	(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-11-(4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; (R)-3,10-Dibromo-8-chloro-11-(piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 193276-49-2; UNII-9F8D9C6J4I; 9F8D9C6J4I; Benzo[5,6]cyclohepta[1,2-b]pyridine, 3,10-dibromo-8-chloro-6,11-dihydro-11-(4-piperidinyl)-, (11R)-; SCHEMBL218062; AOB67717
EINECS	Contact for details

Quality Control

Our 5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine, 3,10-Dibromo-8-Chloro-6,11-Dihydro-11-(4-Piperidinyl)-, (11R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥98.5% (11R)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.