Description

4-{4-[(11S)-3,10-Dibromo-8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridin-11- CAS NO 193275-85-3 is a high-purity, advanced pharmaceutical intermediate characterized by its complex polycyclic structure and specific stereochemistry. This compound is of critical importance for the research and development of novel therapeutic agents, particularly in the field of kinase inhibitors and targeted oncology treatments. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors.
• Oncology Research: Used in the development of targeted cancer therapies due to its specific molecular scaffold.
• Chemical Biology: Serves as a probe or precursor in studying enzyme mechanisms and signal transduction pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and novel compound library generation.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client pipelines.

Basic Information

Product Name	4-{4-[(11S)-3,10-Dibromo-8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridin-11- CAS NO 193275-85-3
CAS No.	193275-85-3
Molecular Formula	C19H15Br2ClN2
Molecular Weight	474.60 g/mol
Synonyms	4-[4-[(11S)-3,10-Dibromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]]; (11S)-3,10-Dibromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine-11-carboxaldehyde; Lorlatinib Intermediate; PF-06463922 Intermediate; ALK/ROS1 Inhibitor Intermediate; Benzo[5,6]cyclohepta[1,2-b]pyridine derivative; 193275-85-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.