Description

(3R,3As,6Ar)-Hexahydrofuro[2,3-B]Furan-3-Yl 4-Nitrophenyl Carbonate is a specialized, high-purity chemical intermediate of significant importance in advanced organic synthesis. Its core value lies in its role as a key building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research and production teams in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex drug molecules, particularly for antiviral and protease inhibitor compounds.
• Protease Inhibitor Synthesis: Used in the construction of key pharmacophores for inhibitors targeting specific viral or cellular proteases.
• Nucleoside/Nucleotide Analog Development: Serves as a protected precursor or coupling agent in the synthesis of modified nucleosides for therapeutic applications.
• Peptidomimetic Chemistry: Employed to introduce the fused bicyclic furan moiety into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Active Ingredient Synthesis: Utilized in the research and development of novel pesticides and herbicides requiring sophisticated heterocyclic cores.
• Fine Chemical and Catalyst Ligand Synthesis: Acts as a precursor for creating chiral ligands or complex organic molecules used in asymmetric catalysis.
• Academic and R&D Laboratories: A valuable reagent for methodological development and exploring new chemical spaces in medicinal and synthetic chemistry.

Basic Information

Product Name	(3R,3As,6Ar)-Hexahydrofuro[2,3-B]Furan-3-Yl 4-Nitrophenyl Carbonate
CAS No.	192725-55-6
Molecular Formula	C₁₃H₁₃NO₇
Molecular Weight	295.25 g/mol
Synonyms	(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl carbonate; 4-Nitrophenyl (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl carbonate; Bicyclic Furan Carbonate Ester; 4-Nitrophenyl Carbonate of Hexahydrofurofuranol; (3R,3aS,6aR)-Perhydrofuro[2,3-b]furan-3-ol, 4-nitrophenyl carbonate; 1,2-O-Isopropylidene-α-D-xylofuranose derivative (related precursor); 4-NPC activated ester
EINECS	Contact for details

Quality Control

Our (3R,3As,6Ar)-Hexahydrofuro[2,3-B]Furan-3-Yl 4-Nitrophenyl Carbonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.