Description

Propanoic Acid, 3-[(1S)-1-[(1S,3Ar,4S,7Ar)-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Octahydro-7A-Methyl-1H-Inden-1-Yl]Ethoxy]-, Ethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined structure. This compound is critical for the synthesis of novel, potent therapeutic agents, particularly in the fields of endocrinology and oncology. It is primarily utilized by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) for the development and production of active pharmaceutical ingredients (APIs).

Application

• Key Intermediate in Steroid-Based Drug Synthesis: Serves as a crucial building block for the production of novel corticosteroids and other steroidal pharmaceuticals.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design and synthesis of new chemical entities targeting hormone receptors.
• Process Chemistry & Scale-Up: Employed in the development of robust, scalable synthetic routes for commercial API manufacturing.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Precursor for Complex Molecule Libraries: Utilized in the generation of specialized compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Propanoic Acid, 3-[(1S)-1-[(1S,3Ar,4S,7Ar)-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Octahydro-7A-Methyl-1H-Inden-1-Yl]Ethoxy]-, Ethyl Ester
CAS No.	192573-35-6
Molecular Formula	C23H44O4Si
Molecular Weight	412.68 g/mol
Synonyms	Ethyl 3-[(1S)-1-[(1S,3aR,4S,7aR)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]octahydro-7a-methyl-1H-inden-1-yl]ethoxy]propanoate; (1S,3aR,4S,7aR)-1-[(1S)-1-(Ethoxycarbonyl)ethoxy]-4-[(tert-butyldimethylsilyl)oxy]-7a-methyloctahydro-1H-indene; TBDMS-protected Steroid Intermediate; tert-Butyldimethylsilyl Ether Steroid Derivative
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical applications. Our products undergo rigorous testing, including chiral purity analysis and impurity profiling, to ensure compliance with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, assay, chiral purity, and related substances is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.