Description

Methyl (2S)-2-(Bis(tert-Butoxycarbonyl)Amino)-5-Oxopentanoate is a high-purity, protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex peptide and peptidomimetic structures, offering researchers precise stereochemical control. This compound is essential for pharmaceutical R&D chemists and process development scientists working on novel therapeutic agents, particularly in the fields of protease inhibitors and bioactive peptide synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially protease inhibitors and peptide-based therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected glutamic acid semialdehyde equivalent or other functionalized amino acid residues.
• Chemical Biology Research: Employed in the design and synthesis of activity-based probes, enzyme substrates, and peptidomimetics for studying biological pathways.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable production of Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Custom Synthesis: A versatile building block for contract research and manufacturing organizations (CROs/CMOs) to create bespoke molecules for client projects.

Basic Information

Product Name	Methyl (2S)-2-(Bis(tert-Butoxycarbonyl)Amino)-5-Oxopentanoate
CAS No.	192314-71-9
Molecular Formula	C17H29NO7
Molecular Weight	359.42 g/mol
Synonyms	Methyl (2S)-2-[(tert-butoxycarbonyl)(tert-butoxycarbonyl)amino]-5-oxopentanoate; (S)-Methyl 2-((Boc)2-amino)-5-oxopentanoate; Boc-Boc-Glu(OMe)-H; N,N-Bis-Boc-L-glutamic acid 1-methyl ester 5-aldehyde; L-Glutamic acid, N,N-bis[(1,1-dimethylethoxy)carbonyl]-, 1-methyl ester; (2S)-2-[Bis(tert-butoxycarbonyl)amino]-5-oxopentanoic acid methyl ester; N,N-Di-Boc-L-glutamic acid α-methyl ester γ-semialdehyde
EINECS	Contact for details

Quality Control

Our Methyl (2S)-2-(Bis(tert-Butoxycarbonyl)Amino)-5-Oxopentanoate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral integrity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of research and development, with capabilities to supply material under cGMP standards for advanced clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the certificate of analysis. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.