Description

Glutamic Acid, n-[[(4-Methoxyphenyl)Thio]Carbonyl]-, Bis(1,1-Dimethylethyl) Ester is a specialized, high-purity chemical intermediate featuring a protected glutamic acid backbone with a unique thiocarbamate linkage. This compound is engineered to provide controlled reactivity and enhanced stability, making it a valuable building block for advanced synthesis. It is primarily utilized by research institutions and pharmaceutical development teams working on novel peptide mimetics, enzyme inhibitors, and prodrug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex molecules for drug discovery and development programs.
• Peptidomimetic Research: Used to construct modified peptide structures where the tert-butyl ester and thiocarbamate groups provide orthogonal protection and functional handles.
• Protease Inhibitor Development: Acts as a core scaffold or a transition-state analog in the design of inhibitors for specific enzymatic targets.
• Chemical Biology Probes: Employed in the creation of activity-based probes (ABPs) or affinity labels to study enzyme function and mechanism.
• Agrochemical Synthesis: Potential intermediate for developing advanced crop protection agents with novel modes of action.
• Material Science: Can be investigated as a monomer or cross-linker for specialty polymers with tailored degradation or recognition properties.

Basic Information

Product Name	Glutamic Acid, n-[[(4-Methoxyphenyl)Thio]Carbonyl]-, Bis(1,1-Dimethylethyl) Ester
CAS No.	192203-59-1
Molecular Formula	C20H29NO5S
Molecular Weight	395.52 g/mol
Synonyms	Di-tert-butyl N-[(4-methoxyphenyl)sulfanyl]carbonyl-L-glutamate; L-Glutamic acid, N-[[(4-methoxyphenyl)thio]carbonyl]-, bis(1,1-dimethylethyl) ester; N-[(4-Methoxyphenyl)thiocarbonyl]glutamic acid di-tert-butyl ester; Bis(tert-butyl) N-((4-methoxyphenyl)carbamothioyl)-L-glutamate; Glutamic acid derivative CAS 192203-59-1; Thiocarbamate-protected glutamic acid diester
EINECS	Contact for details

Quality Control

Our Glutamic Acid, n-[[(4-Methoxyphenyl)Thio]Carbonyl]-, Bis(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications and test results to support your R&D and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.