Description

3-Iodo-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because its unique pyrrolopyridine scaffold, functionalized with both an iodine handle and a protected carboxylic acid, enables precise molecular construction in complex chemical environments. It is primarily needed by medicinal chemistry and process R&D teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of kinase inhibitors, particularly those targeting oncology and inflammatory disease pathways.
• Agrochemical Research: Used in the synthesis of novel herbicides and fungicides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a precursor for functionalized organic semiconductors and light-emitting materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to introduce complex substituents.
• Chemical Biology: Employed as a probe or linker molecule in bioconjugation and target identification studies.
• Academic Research: A valuable tool for methodology development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3-Iodo-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	192189-18-7
Molecular Formula	C12H13IN2O2
Molecular Weight	344.15 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 3-iodo-, 1,1-dimethylethyl ester; tert-Butyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 3-Iodo-1-Boc-7-azaindole; 3-Iodo-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; 1-Boc-3-iodo-7-azaindole; 3-Iodo-7-azaindole-1-carboxylic acid tert-butyl ester; 3-Iodo-1-(tert-butoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 3-Iodo-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.