Description

1-(4-Aminophenyl)-4-Methyl-7,8-Methylenedioxy-5H-2,3-Benzodiazepine Hydrochloride is a high-purity, specialized benzodiazepine derivative in its hydrochloride salt form. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential as a key synthetic intermediate or a pharmacologically active scaffold. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel therapeutic agents targeting the central nervous system. The product is supplied with a focus on consistent quality and reliable supply chain integrity for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Neurological Research: Used as a reference standard or investigational compound in preclinical studies targeting GABA-A receptor modulation and related neurological pathways.
• Medicinal Chemistry: Provides a core scaffold for structure-activity relationship (SAR) studies aimed at developing new anxiolytic, sedative, or anticonvulsant candidates.
• Chemical Synthesis: Employed in organic synthesis for the introduction of the 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-2,3-benzodiazepine moiety into more complex molecules.
• Analytical Standard: Utilized as a high-purity certified reference material (CRM) for method development and quality control in analytical laboratories.

Basic Information

Item	Detail
Product Name	1-(4-Aminophenyl)-4-Methyl-7,8-Methylenedioxy-5H-2,3-Benzodiazepine Hydrochloride
CAS No.	192065-56-8
Molecular Formula	C17H16N3O2Cl
Molecular Weight	329.78 g/mol
Synonyms	1-(4-Aminophenyl)-4-methyl-7,8-(methylenedioxy)-5H-2,3-benzodiazepine hydrochloride; GYKI-52466 dihydrochloride (common research alias); 4-Methyl-7,8-methylenedioxy-1-(4-aminophenyl)-5H-2,3-benzodiazepine HCl; 5H-2,3-Benzodiazepine-1(4H)-carboxamide, 7,8-(methylenedioxy)-4-methyl-N4-phenyl-, hydrochloride (1:?); 192065-56-8; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1-(4-Aminophenyl)-4-Methyl-7,8-Methylenedioxy-5H-2,3-Benzodiazepine Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We are committed to providing materials suitable for use under cGMP guidelines for non-clinical research applications, with specifications tailored to client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.