Description

4-Thia-2,6-Diazabicyclo[3.2.0]Hept-2-Ene-6-Acetic Acid, A-(1-Methylethylidene)-7-Oxo-3-(Phenylmethyl)-, (4-Nitrophenyl)Methyl Ester, (1R,5R)- is a sophisticated bicyclic heterocyclic compound featuring a fused β-lactam structure, making it a valuable advanced pharmaceutical intermediate. Its complex molecular architecture is specifically engineered for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in antibiotic research. This high-purity intermediate is essential for medicinal chemistry programs and process development within the pharmaceutical and biotechnology sectors.

Application

• Key Intermediate in Novel β-Lactam Antibiotic Synthesis: Serves as a critical building block for the research and development of next-generation antibiotics targeting resistant bacterial strains.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for potential API candidates.
• Academic & Institutional Research: Utilized in biochemical and pharmacological studies to explore new mechanisms of action against pathogens.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized, non-commercial drug substances.

Basic Information

Product Name	4-Thia-2,6-Diazabicyclo[3.2.0]Hept-2-Ene-6-Acetic Acid, A-(1-Methylethylidene)-7-Oxo-3-(Phenylmethyl)-, (4-Nitrophenyl)Methyl Ester, (1R,5R)-
CAS No.	192049-49-3
Molecular Formula	C24H23N3O5S
Molecular Weight	465.52 g/mol
Synonyms	(1R,5R)-4-Thia-2,6-diazabicyclo[3.2.0]hept-2-ene-6-acetic acid, α-(1-methylethylidene)-7-oxo-3-(phenylmethyl)-, 4-nitrophenyl methyl ester; (1R,5R)-3-Benzyl-α-isopropylidene-7-oxo-4-thia-2,6-diazabicyclo[3.2.0]hept-2-ene-6-acetic acid 4-nitrophenylmethyl ester; 4-Nitrophenylmethyl (1R,5R)-3-benzyl-α-isopropylidene-7-oxo-4-thia-2,6-diazabicyclo[3.2.0]hept-2-ene-6-acetate; Bicyclic β-lactam intermediate 192049-49-3; Advanced Penem/ Carbapenem synthetic intermediate.
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Our quality assurance includes comprehensive analytical characterization using HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical specifications. We adhere to cGMP guidelines where applicable for the production of pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and prolonged exposure to elevated temperatures; therefore, desiccants are recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.