Description

2H-Pyran-2-One,Tetrahydro-4-Methyl-6-(1-Methylethyl)-,(4R,6S)-Rel-(9Ci) is a high-purity, stereochemically defined lactone compound, identified by CAS NO 191917-39-2, serving as a critical chiral intermediate and building block in advanced organic synthesis. Its defined stereochemistry at the 4 and 6 positions makes it invaluable for the production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of statin drugs and other bioactive molecules requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the research and development of enantiomerically pure pesticides and herbicides.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and other high-value specialty chemicals.
• Academic & Industrial Research: A valuable reagent for methodological development in asymmetric synthesis and catalysis studies.
• Material Science: Potential monomer or modifier for creating polymers with specific optical or physical properties.

Basic Information

Product Name	2H-Pyran-2-One,Tetrahydro-4-Methyl-6-(1-Methylethyl)-,(4R,6S)-Rel-(9Ci)
CAS No.	191917-39-2
Molecular Formula	C9H16O2
Molecular Weight	156.22 g/mol
Synonyms	(4R,6S)-4-Methyl-6-(propan-2-yl)tetrahydro-2H-pyran-2-one; (4R,6S)-6-Isopropyl-4-methyltetrahydro-2H-pyran-2-one; (4R,6S)-Rel-4-Methyl-6-(1-methylethyl)tetrahydro-2H-pyran-2-one; Dihydro-4-methyl-6-(2-propyl)-2H-pyran-2-one (stereoisomer); Lactone intermediate for Atorvastatin; Chiral δ-lactone derivative.
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high enantiomeric excess. Quality is verified through advanced analytical techniques including Chiral HPLC, GC, and NMR to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.