Description

3-(5-Amino-1-Oxo-Isoindolin-2-Yl)Piperidine-2,6-Dione is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing targeted therapies and complex organic molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in oncology and immunology research.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or warhead component in the design of targeted protein degradation therapeutics.
• Cereblon (CRBN) E3 Ligase Modulator Research: Used in studies investigating immunomodulatory imide drug (IMiD) analogs and their mechanisms of action.
• Medicinal Chemistry & Lead Optimization: Employed for structure-activity relationship (SAR) studies to improve drug potency and selectivity.
• Bioconjugation & Chemical Biology: Utilized as a handle for creating chemical probes to study protein function and cellular pathways.
• Contract Research & Manufacturing (CRMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	3-(5-Amino-1-Oxo-Isoindolin-2-Yl)Piperidine-2,6-Dione
CAS No.	191732-70-4
Molecular Formula	C13H14N4O3
Molecular Weight	274.27 g/mol
Synonyms	2-(2,6-Dioxopiperidin-3-yl)-5-aminoisoindoline-1,3-dione; 3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 5-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Lenalidomide Impurity; Lenalidomide Related Compound; CRBN Ligand Derivative; Aminothalidomide Analog; Immunomodulatory Agent Intermediate
EINECS	Contact for details

Quality Control

Our 3-(5-Amino-1-Oxo-Isoindolin-2-Yl)Piperidine-2,6-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical R&D use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider using desiccants and storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.