Description

cis-1-(tert-Butoxycarbonyl)-5-(Methoxycarbonyl)Piperidine-3-Carboxylic Acid is a high-purity, multifunctional piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold for constructing complex molecules with precise three-dimensional architecture. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Peptidomimetic Chemistry: Used to introduce constrained, non-natural amino acid motifs into peptide backbones to enhance stability and biological activity.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the design and synthesis of new generation herbicides and insecticides with improved selectivity.
• Chemical Biology Probes: Utilized to build molecular tools for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring a protected, multi-functionalized piperidine core.

Basic Information

Product Name	cis-1-(tert-Butoxycarbonyl)-5-(Methoxycarbonyl)Piperidine-3-Carboxylic Acid
CAS No.	191544-72-6
Molecular Formula	C13H21NO6
Molecular Weight	287.31 g/mol
Synonyms	1-Boc-5-(Methoxycarbonyl)piperidine-3-carboxylic acid (cis); (3S,5R)-1-(tert-Butoxycarbonyl)-5-(methoxycarbonyl)piperidine-3-carboxylic acid; (3R,5S)-1-Boc-5-(methoxycarbonyl)piperidine-3-carboxylic acid; cis-1-N-Boc-5-carbonethoxypiperidine-3-carboxylic acid; Boc-5-COOMe-piperidine-3-COOH (cis); 1-(tert-Butyloxycarbonyl)-5-methoxycarbonylpiperidine-3-carboxylic acid (cis); Piperidine-3-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-5-(methoxycarbonyl)-, (3R,5S)-rel-
EINECS	Contact for details

Quality Control

Our cis-1-(tert-Butoxycarbonyl)-5-(Methoxycarbonyl)Piperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and standard pharmacopeial identification tests. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.