Description

(S)-1-Boc-2-(Methylaminomethyl)-Pyrrolidine is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in modern organic synthesis. This compound is valued for its role in introducing a protected methylamino-methyl side chain in a stereochemically defined manner, enabling the construction of complex molecules with high enantiomeric purity. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of chiral amines and peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, especially those targeting neurological and metabolic disorders.
• Asymmetric Synthesis: Employed as a versatile chiral auxiliary or ligand precursor in catalytic asymmetric reactions to control stereochemistry.
• Peptidomimetic Chemistry: Used to construct proline-like scaffolds and conformationally constrained peptide analogs for medicinal chemistry programs.
• API Development: Integral in the synthetic pathways for complex molecules where the introduction of a protected (S)-2-(aminomethyl)pyrrolidine structure is required.
• Chemical Biology Probes: Serves as a building block for creating labeled compounds and molecular probes used in biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high chiral purity.

Basic Information

Product Name	(S)-1-Boc-2-(Methylaminomethyl)-Pyrrolidine
CAS No.	191231-58-0
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-2-((methylamino)methyl)pyrrolidine; (S)-2-((Methylamino)methyl)-1-Boc-pyrrolidine; (S)-N-Boc-2-(Methylaminomethyl)pyrrolidine; (S)-1-Boc-2-(Methylaminomethyl)azolidine; tert-Butyl (S)-2-((methylamino)methyl)pyrrolidine-1-carboxylate; (S)-1-Boc-2-(Methylaminomethyl)pyrrolidine; (S)-N-Boc-N-methyl-2-pyrrolidinemethanamine; (S)-2-(Methylaminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-2-(Methylaminomethyl)-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.