Description

2-(5-Bromo-Pyridin-3-Yloxymethyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, offering a protected pyrrolidine scaffold and a reactive bromopyridine moiety for further functionalization. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, especially those targeting neurological disorders.
• Protease Inhibitor Research: Used in the development of protease inhibitors, a key class of drugs for antiviral and anticancer applications.
• Ligand Synthesis for Drug Discovery: Serves as a precursor for creating specialized ligands and molecular scaffolds in medicinal chemistry programs.
• Chemical Biology & Probe Development: Employed in the synthesis of chemical probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Used in process research and development (PR&D) for optimizing synthetic routes to potential APIs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific compounds.

Basic Information

Product Name	2-(5-Bromo-Pyridin-3-Yloxymethyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	191162-30-8
Molecular Formula	C16H23BrN2O3
Molecular Weight	371.27 g/mol
Synonyms	tert-Butyl 2-[[(5-bromo-3-pyridinyl)oxy]methyl]-1-pyrrolidinecarboxylate; 1-Boc-2-((5-bromo-3-pyridyloxy)methyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-2-((5-bromo-3-pyridyloxy)methyl)pyrrolidine; 2-((5-Bromopyridin-3-yloxy)methyl)pyrrolidine-1-carboxylic acid tert-butyl ester; N-Boc-2-((5-bromo-3-pyridyloxy)methyl)pyrrolidine; 191162-30-8
EINECS	Contact for details

Quality Control

Our 2-(5-Bromo-Pyridin-3-Yloxymethyl)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.