Description

Methyl 1-{[(tert-Butoxy)Carbonyl]Amino}-3-Hydroxycyclobutane-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a cyclobutane scaffold with protected amine and carboxylic acid functionalities. This compound is critically important for enabling the synthesis of complex, conformationally constrained active pharmaceutical ingredients (APIs) and novel drug candidates. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutics, particularly in areas requiring rigid, three-dimensional molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Protease Inhibitor Synthesis: Used in the research and development of protease inhibitors, where the cyclobutane ring provides critical steric and conformational properties.
• Peptidomimetic Chemistry: Serves as a constrained amino acid analog in the design and synthesis of peptidomimetics to enhance metabolic stability and bioavailability.
• Chemical Biology Research: Employed as a tool compound for studying enzyme-substrate interactions and for probing biological pathways that involve specific three-dimensional recognition.
• Medicinal Chemistry & Lead Optimization: Facilitates structure-activity relationship (SAR) studies by introducing a rigid, aliphatic ring system into molecular scaffolds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and niche APIs.

Basic Information

Product Name	Methyl 1-{[(tert-Butoxy)Carbonyl]Amino}-3-Hydroxycyclobutane-1-Carboxylate
CAS No.	191110-53-9
Molecular Formula	C12H21NO5
Molecular Weight	259.30 g/mol
Synonyms	1-[(tert-Butoxycarbonyl)amino]-3-hydroxycyclobutane-1-carboxylic acid methyl ester; Methyl 1-((tert-butoxycarbonyl)amino)-3-hydroxycyclobutane-1-carboxylate; 1-N-Boc-amino-3-hydroxycyclobutane-1-carboxylic acid methyl ester; 1-(Boc-amino)-3-hydroxycyclobutane-1-carboxylic acid methyl ester; (1R,3S)-rel-1-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxycyclobutane-1-carboxylic acid methyl ester; Methyl 1-(Boc-amino)-3-hydroxycyclobutanecarboxylate; 191110-53-9
EINECS	Contact for details

Quality Control

Our Methyl 1-{[(tert-Butoxy)Carbonyl]Amino}-3-Hydroxycyclobutane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.