Description

1-Methyl-5-Oxoproline Methyl Ester is a high-purity, specialized organic building block of significant interest in advanced chemical synthesis. This compound serves as a critical intermediate for the development of novel pharmaceuticals and bioactive molecules, particularly in peptide mimetics and protease inhibitor research. It is essential for R&D and production chemists in the pharmaceutical, biotechnology, and fine chemical sectors seeking to introduce constrained proline-like structures into target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially protease inhibitors and peptide-based therapeutics.
• Peptidomimetics Research: Used to create constrained amino acid analogs that mimic peptide structures with enhanced metabolic stability and bioavailability.
• Fine Chemical Synthesis: Serves as a versatile chiral synthon in multi-step organic synthesis for complex natural products and specialty chemicals.
• Bioconjugation Chemistry: Potential use in linker chemistry for creating antibody-drug conjugates (ADCs) or other bioconjugates due to its reactive ester group.
• Academic & Industrial R&D: Employed in research laboratories for methodological development and exploring new chemical entities.

Basic Information

Product Name	1-Methyl-5-Oxoproline Methyl Ester
CAS No.	190783-99-4
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	Methyl 1-methyl-5-oxopyrrolidine-2-carboxylate; 1-Methyl-5-oxo-D-proline methyl ester; Methyl 1-methyl-5-oxoproline; 1-Methyl-5-oxoproline methyl ester; 1-Methyl-5-oxo-L-proline methyl ester (if applicable to specific enantiomer); 1-Methyl-5-oxopyrrolidine-2-carboxylic acid methyl ester; Proline derivative, 1-methyl-5-oxo-, methyl ester
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-Oxoproline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis (if applicable), and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (if applicable)	Contact for details
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.