Description

4-Fluoro-2-(Trifluoromethyl)Phenyl Isocyanate is a specialized aromatic isocyanate building block characterized by its unique fluorine-substituted phenyl ring. This compound is critical for introducing the 4-fluoro-2-(trifluoromethyl)phenylcarbamoyl moiety into target molecules, enabling the fine-tuning of physical, chemical, and biological properties. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active ingredients, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance bioactivity and environmental stability.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for producing specialty polyurethanes, polyureas, and coatings with enhanced chemical resistance and weatherability.
• Liquid Crystal & OLED Materials: Incorporated into the molecular structure of electronic materials to modify dielectric properties, thermal stability, and emission characteristics.
• Chemical Research & Development: Essential reagent for academic and industrial research focused on organofluorine chemistry, medicinal chemistry, and novel heterocycle formation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific compounds and proprietary derivatives.

Basic Information

Product Name	4-Fluoro-2-(Trifluoromethyl)Phenyl Isocyanate
CAS No.	190774-54-0
Molecular Formula	C8H3F4NO
Molecular Weight	205.11 g/mol
Synonyms	1-Isocyanato-4-fluoro-2-(trifluoromethyl)benzene; 4-Fluoro-α,α,α-trifluoro-o-tolyl isocyanate; 2-(Trifluoromethyl)-4-fluorophenyl isocyanate; 4-Fluoro-2-trifluoromethylphenyl isocyanate; 4-Fluoro-α,α,α-trifluoro-o-toluene isocyanate; NSC 405124; 190774-54-0
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Trifluoromethyl)Phenyl Isocyanate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture and to maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.