Description

2-Fluoro-3-(trifluoromethyl)phenyl isocyanate is a highly reactive aromatic isocyanate derivative, distinguished by its unique fluorine-substituted phenyl ring. This compound is a critical building block in advanced organic synthesis, valued for its ability to introduce both the isocyanate functional group and fluorinated aromatic moieties into target molecules. It is primarily sought by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly urea and carbamate derivatives.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing potential drug candidates, especially urea-based compounds with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the fluorinated aromatic group can improve lipophilicity and biological activity.
• Polymer Modification: Serves as a monomer or cross-linking agent in the production of specialty polyurethanes and polyurea coatings with specific chemical resistance properties.
• Material Science Research: Employed in creating novel organic frameworks, liquid crystals, or functional materials that require precise incorporation of fluorinated aromatic isocyanates.
• Chemical Biology Probes: Useful for labeling biomolecules or synthesizing activity-based probes to study enzyme function, leveraging the reactivity of the isocyanate group.

Basic Information

Product Name	2-Fluoro-3-(trifluoromethyl)phenyl Isocyanate
CAS No.	190774-52-8
Molecular Formula	C8H3F4NO
Molecular Weight	205.11 g/mol
Synonyms	2-Fluoro-3-(trifluoromethyl)phenyl isocyanate; 2-Fluoro-alpha,alpha,α-trifluoro-m-tolyl isocyanate; 1-Fluoro-2-isocyanato-6-(trifluoromethyl)benzene; 3-Isocyanato-2-fluorobenzotrifluoride; m-Tolyl, 2-fluoro-alpha,alpha,α-trifluoro-, isocyanate; Isocyanic acid, 2-fluoro-3-(trifluoromethyl)phenyl ester
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-(trifluoromethyl)phenyl isocyanate is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic processes. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and hygroscopic (moisture-sensitive) nature, this material must be stored under a dry, inert atmosphere (e.g., nitrogen or argon) in a cool, well-ventilated area. Recommended storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress and pressure changes.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.