Description

(3S,5S)-3,5-Bis(tert-Butyldimethylsilyloxy)-2-Methyl-1-Cyclohexen-1-Ol 1-Trifluoromethanesulfonate is a high-value, protected chiral building block and advanced pharmaceutical intermediate. This compound is critical for its role in the stereoselective synthesis of complex organic molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. The CAS number for this compound is 189894-13-1.

Application

This specialized intermediate is designed for high-precision synthetic applications, particularly in regulated industries.

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized in stereocontrolled reactions to construct specific molecular configurations essential for biological activity.
• Medicinal Chemistry Research: Serves as a critical building block for constructing novel molecular scaffolds in drug discovery and development programs.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Fine Chemical Production: Employed in the manufacture of high-value specialty chemicals requiring precise stereochemistry.
• Academic Research: A valuable reagent for methodological studies in organic synthesis and catalysis at universities and R&D institutes.

Basic Information

Product Name	(3S,5S)-3,5-Bis(tert-Butyldimethylsilyloxy)-2-Methyl-1-Cyclohexen-1-Ol 1-Trifluoromethanesulfonate
CAS No.	189894-13-1
Molecular Formula	C20H39F3O6SSi2
Molecular Weight	520.75 g/mol
Synonyms	(3S,5S)-3,5-Bis[(1,1-dimethylethyl)dimethylsilyl]oxy-2-methyl-1-cyclohexen-1-ol trifluoromethanesulfonate; (3S,5S)-3,5-Bis-O-(tert-butyldimethylsilyl)-2-methyl-1-cyclohexen-1-ol triflate; (3S,5S)-3,5-Bis(TBDMSO)-2-methyl-1-cyclohexen-1-ol trifluoromethanesulfonate; TBS-protected cyclohexenol triflate; Chiral TBS-ether triflate intermediate; 2-Methyl-1-cyclohexen-1-ol, 3,5-bis[(1,1-dimethylethyl)dimethylsilyl]oxy-, (3S,5S)-, 1-trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity, typically including HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong bases.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.