Description

Cyclopropanecarboxylic Acid, 2-Acetyl-3-Methyl-, Ethyl Ester, (1R,2R,3R)-Rel- is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures with precise three-dimensional control, which is critical for developing active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce the cyclopropane moiety, a privileged structural motif known to enhance metabolic stability and modulate biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and antiviral drugs.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the cyclopropane ring contributes to biological efficacy and environmental profile.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new stereoselective synthetic methodologies.
• Fine Chemical Manufacturing: Acts as a building block for synthesizing flavors, fragrances, and other high-value specialty chemicals requiring specific stereochemistry.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal or mechanical properties.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Acetyl-3-Methyl-, Ethyl Ester, (1R,2R,3R)-Rel-
CAS No.	189628-51-1
Molecular Formula	C10H16O3
Molecular Weight	184.23 g/mol
Synonyms	(1R,2R,3R)-rel-2-Acetyl-3-methylcyclopropanecarboxylic acid ethyl ester; Ethyl (1R,2R,3R)-rel-2-acetyl-3-methylcyclopropanecarboxylate; Ethyl 2-acetyl-3-methylcyclopropanecarboxylate (rel-(1R,2R,3R)-); rel-(1R,2R,3R)-Ethyl 2-acetyl-3-methylcyclopropanecarboxylate; 2-Acetyl-3-methylcyclopropanecarboxylic Acid Ethyl Ester (rel-(1R,2R,3R)-); Chiral Cyclopropane Ester Intermediate
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. The product undergoes rigorous analytical testing, including chiral HPLC and GC/MS, to confirm identity, stereochemical purity, and chemical purity. Certificates of Analysis (COA) detailing specific results for each lot are available upon request, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (rel-(1R,2R,3R)-)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.