Description

3-Azido-2,3-dideoxy-1-O-(tert-butyldimethylsilyl)-D-ribofuranose is a specialized nucleoside derivative and a key synthetic intermediate in organic and medicinal chemistry. This compound is valued for its unique azido and protected sugar functionalities, which are essential for constructing complex molecules via click chemistry and other advanced synthetic routes. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel antiviral agents, nucleotide analogs, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral drug candidates.
• Click Chemistry Substrate: The azido group enables efficient, high-yielding Huisgen 1,3-dipolar cycloaddition reactions for bioconjugation and material science applications.
• Nucleotide Analog Synthesis: Used in the research and development of modified nucleotides for therapeutic and diagnostic applications.
• Glycochemistry Research: Serves as a protected sugar derivative for studying glycosylation reactions and carbohydrate-based drug design.
• Proteomics and Chemical Biology: Employed as a chemical probe or tag for labeling biomolecules to study biological processes.
• Process Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) requiring modified sugar moieties.

Basic Information

Product Name	3-Azido-2,3-dideoxy-1-O-(tert-butyldimethylsilyl)-D-ribofuranose
CAS No.	189454-43-1
Molecular Formula	C13H27N3O4Si
Molecular Weight	317.46 g/mol
Synonyms	1-O-(tert-Butyldimethylsilyl)-3-azido-2,3-dideoxy-D-ribofuranose; 3-Azido-2,3-dideoxy-1-O-TBDMS-D-ribofuranose; 3-Azido-2,3-dideoxy-1-O-[(1,1-dimethylethyl)dimethylsilyl]-D-ribofuranose; 1-O-TBDMS-3-azido-2,3-dideoxy-D-ribofuranose; TBDMS-Protected 3-Azido-2,3-dideoxy-D-ribose; 3-Azido-2,3-dideoxy-D-ribofuranose 1-O-tert-butyldimethylsilyl ether; 189454-43-1
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with typical purity levels suitable for research and process development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality management system supports the needs of customers operating under cGMP and ISO guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Contact for specific grade)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.