Description

2-Piperidinecarboxylicacid,4-Hydroxy-,(2R,4R)-(9Ci) is a high-purity chiral piperidine derivative, a critical building block in advanced organic synthesis. Its stereochemical purity and functional groups make it an invaluable intermediate for creating complex molecules with specific biological activity. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for neurological and metabolic disorders. We supply this material with guaranteed batch-to-batch consistency to support your most demanding R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, receptor antagonists, and other small-molecule therapeutics.
• Asymmetric Catalysis Research: Used as a precursor or ligand in the development of novel chiral catalysts for stereoselective reactions.
• Peptidomimetics Development: Serves as a constrained amino acid analog for constructing peptide-like molecules with enhanced stability and bioavailability.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2-Piperidinecarboxylicacid,4-Hydroxy-,(2R,4R)-(9Ci)
CAS No.	189385-64-6
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(2R,4R)-4-Hydroxypipecolic Acid; (2R,4R)-4-Hydroxy-2-piperidinecarboxylic Acid; trans-4-Hydroxy-D-pipecolic Acid; (2R,4R)-HPA; 4-Hydroxy-D-pipecolic Acid; 189385-64-6; (2R,4R)-4-Hydroxypipecolate
EINECS	Contact for details

Quality Control

Every batch of (2R,4R)-4-Hydroxypipecolic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure stereochemical purity and chemical identity meet the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.