Description

tert-Butyl 3-Isocyanatopiperidine-1-Carboxylate CAS NO 189321-64-0 is a versatile and high-value piperidine-based building block featuring a reactive isocyanate group protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for the efficient synthesis of complex molecules, particularly in pharmaceutical research and development. It serves as a key intermediate for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially in the areas of central nervous system (CNS) and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly those targeting neurological and psychiatric disorders.
• Peptide Mimetic Synthesis: Used to incorporate constrained piperidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Urea and Carbamate Library Synthesis: The isocyanate group enables efficient high-throughput synthesis of diverse urea and carbamate derivatives for screening.
• Bioconjugation and Linker Chemistry: Employed in the development of antibody-drug conjugates (ADCs) and other targeted therapies where a stable, cleavable linker is required.
• Agrochemical Research: Serves as an intermediate in the development of new crop protection agents with novel modes of action.
• Material Science: Used in the synthesis of specialty polymers and resins where the incorporation of a heterocyclic moiety can modify material properties.

Basic Information

Product Name	tert-Butyl 3-Isocyanatopiperidine-1-Carboxylate
CAS No.	189321-64-0
Molecular Formula	C11H18N2O3
Molecular Weight	226.27 g/mol
Synonyms	1-Boc-3-isocyanatopiperidine; 1-(tert-Butoxycarbonyl)-3-isocyanatopiperidine; 3-Isocyanato-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; Piperidine-1-carboxylic acid, 3-isocyanato-, 1,1-dimethylethyl ester; tert-Butyl 3-isocyanato-1-piperidinecarboxylate; Boc-3-isocyanatopiperidine; 1-N-Boc-3-isocyanatopiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Isocyanatopiperidine-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to support cGMP (current Good Manufacturing Practice) compliance for advanced intermediates, and we can accommodate custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.