Description

2-Pyridinamine, 5-Chloro-3,6-Difluoro- is a high-purity, halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the chloro and difluoro substitutions can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in fine chemical manufacturing.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or components for OLEDs, due to its electron-deficient pyridine core.
• Fluorinated Building Block: Provides a source of fluorine atoms for further functionalization in fluorination chemistry, a valuable tool in modern synthesis.

Basic Information

Product Name	2-Pyridinamine, 5-Chloro-3,6-Difluoro-
CAS No.	189281-75-2
Molecular Formula	C5H3ClF2N2
Molecular Weight	164.54 g/mol
Synonyms	5-Chloro-3,6-difluoropyridin-2-amine; 2-Amino-5-chloro-3,6-difluoropyridine; 5-Chloro-3,6-difluoro-2-pyridinamine; 3,6-Difluoro-5-chloro-2-aminopyridine; 2-Pyridinamine, 5-chloro-3,6-difluoro-; 5-Chloro-3,6-difluoro-2-aminopyridine; 189281-75-2; 5-Chloro-3,6-difluoropyridine-2-amine
EINECS	Contact for details

Quality Control

Our 2-Pyridinamine, 5-Chloro-3,6-Difluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.