Description

2-Bromo-6-(Trifluoromethyl)Pyridine is a high-value halogenated pyridine derivative, distinguished by its bromine and trifluoromethyl substituents which impart unique reactivity and physicochemical properties. This compound is a critical pharmaceutical intermediate and agrochemical building block, enabling the synthesis of complex molecules with enhanced biological activity and metabolic stability. It is primarily utilized by R&D chemists and process development scientists in the life sciences and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form complex biaryl and heteroaryl structures.
• Ligand and Catalyst Development: Employed in the design of novel nitrogen-containing ligands for transition metal catalysis.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Bromo-6-(Trifluoromethyl)Pyridine
CAS No.	189278-27-1
Molecular Formula	C6H3BrF3N
Molecular Weight	225.99 g/mol
Synonyms	2-Bromo-6-(trifluoromethyl)pyridine; 6-Bromo-2-(trifluoromethyl)pyridine; 2-Bromo-α,α,α-trifluoro-6-picoline; Pyridine, 2-bromo-6-(trifluoromethyl)-; 189278-27-1; 2-Bromo-6-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.