Description

(2S,4R)-1-Benzyl 2-Methyl 4-((tert-Butoxycarbonyl)Amino)Pyrrolidine-1,2-Dicarboxylate is a high-purity, stereochemically defined chiral building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other complex therapeutic agents. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially protease inhibitors.
• Peptidomimetic Research: Used to introduce constrained pyrrolidine scaffolds into peptide analogs to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective chemical transformations.
• API Development: Critical for constructing the core structure in the research and scale-up of new Active Pharmaceutical Ingredients.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to explore new chemical entities for therapeutic targets.
• Custom Synthesis: Serves as a building block for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for clients.

Basic Information

Product Name	(2S,4R)-1-Benzyl 2-Methyl 4-((tert-Butoxycarbonyl)Amino)Pyrrolidine-1,2-Dicarboxylate
CAS No.	189215-90-5
Molecular Formula	C20H28N2O6
Molecular Weight	392.45 g/mol
Synonyms	1-Benzyl 2-methyl (2S,4R)-4-[(tert-butoxycarbonyl)amino]pyrrolidine-1,2-dicarboxylate; Boc-4-Amino-(2S,4R)-proline Benzyl Ester Methyl Ester; (2S,4R)-1-(Benzyloxycarbonyl)-2-(methoxycarbonyl)-4-[(tert-butoxycarbonyl)amino]pyrrolidine; (2S,4R)-4-(Boc-Amino)-1-Cbz-2-methoxycarbonylpyrrolidine; N-Boc-4-Amino-(2S,4R)-proline(1-Benzyl 2-Methyl Ester); 189215-90-5; (2S,4R)-1-Cbz-2-OMe-4-N-Boc-pyrrolidine
EINECS	Contact for details

Quality Control

Our (2S,4R)-1-Benzyl 2-Methyl 4-((tert-Butoxycarbonyl)Amino)Pyrrolidine-1,2-Dicarboxylate is manufactured under controlled conditions to ensure exceptional chiral purity and chemical integrity, suitable for demanding pharmaceutical applications. Each batch is subjected to rigorous analytical testing, including chiral HPLC, to confirm identity, purity, and stereochemical composition. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and internal quality standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.