Description

1-Piperidinecarboxylic Acid, 4-(Methylsulfonyl)-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and sulfonyl-protecting group. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling the development of novel therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery and scale-up projects.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Protease Inhibitor Synthesis: Used in the construction of complex molecules designed to inhibit specific enzymes, such as proteases involved in various disease pathways.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog for creating stable peptide-like structures with enhanced pharmacological properties.
• Chemical Biology Research: Employed as a tool compound or building block in the study of biological processes and the development of chemical probes.
• Scale-Up and Process Chemistry: Supplied in development and commercial quantities for the optimization and manufacturing of clinical trial materials and commercial APIs.
• Custom Synthesis: A starting point for the custom synthesis of more complex, proprietary molecules for specialized client applications.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-(Methylsulfonyl)-, 1,1-Dimethylethyl Ester
CAS No.	189205-49-0
Molecular Formula	C11H21NO4S
Molecular Weight	263.35 g/mol
Synonyms	tert-Butyl 4-(methylsulfonyl)piperidine-1-carboxylate; 4-Methanesulfonyl-piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(methylsulfonyl)piperidine; 1-Boc-4-(methylsulfonyl)piperidine; N-Boc-4-(methylsulfonyl)piperidine; 4-(Methylsulfonyl)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(methylsulfonyl)piperidine
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 4-(Methylsulfonyl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.