Description

Ro 48-8071 is a high-purity, non-peptidic farnesyltransferase inhibitor with the CAS registry number 189197-69-1. This compound is a critical research tool for investigating signal transduction pathways, particularly those involving Ras oncoproteins, which are implicated in various cancers. It is essential for pharmaceutical R&D, biochemistry, and oncology research laboratories focused on developing novel therapeutic agents.

Application

• Biochemical Research: Used as a potent and selective inhibitor to study the role of farnesyltransferase in protein prenylation and cell signaling pathways.
• Oncology Research: A key tool compound for in vitro and in vivo studies targeting Ras-dependent tumorigenesis and exploring anticancer strategies.
• Pharmaceutical Development: Serves as a reference standard and lead compound in the discovery and development of novel farnesyltransferase inhibitors.
• Cell Biology Studies: Employed to investigate the effects of inhibiting protein farnesylation on cell proliferation, differentiation, and apoptosis.
• Enzyme Inhibition Assays: Used to characterize farnesyltransferase activity and screen for new inhibitory compounds in high-throughput formats.

Basic Information

Product Name	Ro 48-8071
CAS No.	189197-69-1
Molecular Formula	C27H30F3N3O4
Molecular Weight	517.55 g/mol
Synonyms	4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide; FTI-277; Farnesyltransferase Inhibitor III; (+)-(R)-FTI-277; (R)-FTI 277; Ro 48-8071 fumarate; B581
EINECS	Contact for details

Quality Control

Every batch of Ro 48-8071 (CAS 189197-69-1) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes comprehensive characterization by HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with our stringent in-house specifications for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.