Description

Cyclobutanecarboxylic Acid, 1-Amino-3-Phosphono-, trans- (9Ci) is a high-purity, multifunctional organic compound featuring a cyclobutane backbone integrated with amino and phosphonic acid functional groups. This unique structure makes it a valuable advanced pharmaceutical intermediate and a versatile building block for the synthesis of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in protease inhibitor and nucleotide analog research.
• Agrochemical Synthesis: Serves as a precursor for designing new herbicides and plant growth regulators with targeted activity.
• Ligand and Chelator Development: The phosphonic acid moiety enables its use in creating metal-chelating agents for catalysis or diagnostic imaging.
• Peptidomimetic Research: Used to construct conformationally restricted peptide analogs for biological studies and therapeutic applications.
• Material Science Monomer: Potential building block for specialty polymers and functionalized surfaces due to its reactive functional groups.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and inhibitors for studying enzyme function.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 1-Amino-3-Phosphono-, trans- (9Ci)
CAS No.	189143-41-7
Molecular Formula	C5H10NO5P
Molecular Weight	195.11 g/mol
Synonyms	trans-1-Amino-3-phosphonocyclobutanecarboxylic acid; (1R,3S)-1-Amino-3-phosphonocyclobutanecarboxylic acid; (1S,3R)-1-Amino-3-phosphonocyclobutanecarboxylic acid; APCB; 1-Amino-3-phosphonocyclobutane-1-carboxylic acid; Cyclobutane-1-amino-3-phosphonocarboxylic acid; NSC 760326
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 1-Amino-3-Phosphono-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure it meets the stringent requirements for advanced R&D and scale-up. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.