Description

5-(Azidomethyl)-3,3-Difluorodihydro-2(3H)-Furanone is a high-value, multi-functional heterocyclic building block containing both azide and difluorinated lactone moieties. This unique structure makes it a critical intermediate for the synthesis of complex molecules, particularly in advanced pharmaceutical research and agrochemical development. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting enzyme inhibition or protein degradation (e.g., PROTACs).
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the difluoro and azide groups for bioactivity.
• Click Chemistry Reagent: The azidomethyl group enables efficient, high-yielding Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and material science applications.
• Fluorine Chemistry Research: Serves as a versatile precursor for introducing gem-difluoro motifs into target molecules, which can improve metabolic stability and membrane permeability.
• Polymer & Material Science: Potential monomer or cross-linking agent for creating specialty polymers with unique thermal or chemical resistance properties.

Basic Information

Product Name	5-(Azidomethyl)-3,3-Difluorodihydro-2(3H)-Furanone
CAS No.	189136-13-8
Molecular Formula	C5H5F2N3O2
Molecular Weight	177.11 g/mol
Synonyms	3,3-Difluoro-5-(azidomethyl)dihydrofuran-2(3H)-one; 5-(Azidomethyl)-3,3-difluorodihydrofuran-2(3H)-one; 3,3-Difluoro-5-(azidomethyl)tetrahydrofuran-2-one; 2(3H)-Furanone, dihydro-5-(azidomethyl)-3,3-difluoro-; Azidomethyl difluorodihydrofuranone
EINECS	Contact for details

Quality Control

Our 5-(Azidomethyl)-3,3-Difluorodihydro-2(3H)-Furanone is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support custom synthesis and can tailor specifications to meet specific project requirements, including compliance with ISO and cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to prevent decomposition. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.