Description

1-Benzenesulfonyl-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid is a high-purity, heterocyclic carboxylic acid derivative featuring a benzenesulfonyl protecting group, making it a critical synthetic intermediate for advanced pharmaceutical research and development. Its molecular architecture is specifically designed to serve as a key building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing novel drug candidates, especially kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A pivotal building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitor drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Bioconjugation & Probe Synthesis: Serves as a precursor for creating fluorescent probes or affinity labels for biochemical and diagnostic applications.
• Chemical Biology: Employed in the development of chemical tools to study enzyme function and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and novel drug candidates.

Basic Information

Item	Details
Product Name	1-Benzenesulfonyl-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid
CAS No.	189089-90-5
Molecular Formula	C15H10N2O4S
Molecular Weight	314.32 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 1-(phenylsulfonyl)-; 1-(Phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 1-Benzenesulfonyl-1H-7-azaindole-2-carboxylic acid; 1-(Benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 7-Azaindole-2-carboxylic acid, 1-(phenylsulfonyl)-; 1-(Phenylsulfonyl)-7-azaindole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Benzenesulfonyl-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.