Description

Lapaquistat is a selective, potent inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. This compound is a critical research tool for studying lipid metabolism and the development of novel therapeutic agents targeting hypercholesterolemia. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cardiovascular and metabolic disease research.

Application

• Pharmacological Research: Used as a reference standard and active compound in studies investigating cholesterol biosynthesis inhibition.
• Biochemical Assay Development: Serves as a key inhibitor in enzymatic assays for squalene synthase activity screening.
• Drug Discovery & Development: A vital intermediate and tool compound in the preclinical research phase for novel lipid-lowering agents.
• Mechanistic Studies: Employed to elucidate the biochemical pathways and cellular effects of squalene synthase inhibition.
• Academic Research: Supports fundamental scientific investigations in biochemistry, cell biology, and pharmacology related to lipid metabolism.

Basic Information

Product Name	Lapaquistat
CAS No.	189060-13-7
Molecular Formula	C27H44N2O5S
Molecular Weight	508.72 g/mol
Synonyms	TAK-475; Lapaquistat acetate; (3R,5S)-7-[3-(Benzylsulfonyl)amino]-5-ethyl-1,3-dihydro-2H-indol-2-yl]-3,5-dihydroxyheptanoic acid; Squalene synthase inhibitor TAK-475; BMS-188494; ER-28448; Lapaquistat (acetate)
EINECS	Contact for details

Quality Control

Our Lapaquistat is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support research standards compliant with common pharmacopeial guidelines for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.