Description

Spiro[3H-Indole-3,4'-Piperidine], 1,2-Dihydro-, Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic indole-piperidine structure. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for synthesizing novel bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the development of central nervous system (CNS) and oncological therapeutics. The dihydrochloride salt form enhances stability and solubility, facilitating downstream synthetic processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates targeting serotonin and dopamine receptors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• CNS Drug Development: Employed in the R&D of novel therapeutics for neurological disorders such as depression, anxiety, and schizophrenia.
• Oncology Research: Investigated as a building block for small molecules designed to modulate specific protein-protein interactions in cancer pathways.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological mechanisms and target validation.
• Process Chemistry: Serves as a starting material for scaling up the production of active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Product Name	Spiro[3H-Indole-3,4'-Piperidine], 1,2-Dihydro-, Dihydrochloride
CAS No.	188979-63-7
Molecular Formula	C13H18Cl2N2
Molecular Weight	273.20 g/mol
Synonyms	1,2-Dihydrospiro[3H-indole-3,4'-piperidine] dihydrochloride; Spiro[indoline-3,4'-piperidine] dihydrochloride; 1,2-Dihydrospiro[indole-3,4'-piperidine] dihydrochloride; 1',2'-Dihydrospiro[piperidine-4,3'-indole] dihydrochloride; 2,3-Dihydro-1H-spiro[indole-3,4'-piperidine] dihydrochloride; Spiro[indole-3,4'-piperidine] dihydrochloride; 188979-63-7 (CAS)
EINECS	Contact for details

Quality Control

Every batch of Spiro[3H-Indole-3,4'-Piperidine], 1,2-Dihydro-, Dihydrochloride is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles. We support development from research to commercial scale with consistent quality, ensuring reliable supply for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.