Description

Isopropyl 4,4,4-Trifluoromethylcrotonate is a high-value fluorinated building block and specialty monomer, essential for introducing the trifluoromethyl group into complex molecular architectures. Its core value lies in enabling the synthesis of advanced materials and active pharmaceutical ingredients (APIs) with enhanced properties such as metabolic stability, lipophilicity, and chemical resistance. This compound is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced polymer industries for developing next-generation products.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging the trifluoromethyl group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine moiety enhances biological activity and environmental persistence.
• Specialty Polymer Monomer: Serves as a monomer for creating fluorinated polymers and coatings with superior chemical resistance, low surface energy, and enhanced durability.
• Organic Synthesis Reagent: Acts as a versatile Michael acceptor and fluorinated synthon in complex organic transformations for fine chemical and material science research.
• Liquid Crystal & Electronic Materials: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and organic electronic materials.
• Cross-coupling Reactions: Useful substrate in palladium-catalyzed cross-coupling reactions to construct complex fluorinated aromatic and heteroaromatic systems.

Basic Information

Item	Detail
Product Name	Isopropyl 4,4,4-Trifluoromethylcrotonate
CAS No.	188966-82-7
Molecular Formula	C8H11F3O2
Molecular Weight	196.17 g/mol
Synonyms	Isopropyl 4,4,4-Trifluorobut-2-enoate; 4,4,4-Trifluoromethylcrotonic Acid Isopropyl Ester; Isopropyl (E)-4,4,4-Trifluorobut-2-enoate; (E)-Isopropyl 4,4,4-trifluorobut-2-enoate; 2-Butenoic acid, 4,4,4-trifluoro-, 1-methylethyl ester; Isopropyl β-Trifluoromethylacrylate; 1-Methylethyl 4,4,4-trifluoro-2-butenoate
EINECS	Contact for details

Quality Control

Our Isopropyl 4,4,4-Trifluoromethylcrotonate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates and ISO standards for industrial chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Isomer Ratio (E/Z)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.