Description

3,4-Pyrrolidinediol, 2-(Hydroxymethyl)-1-(2,2,2-Trifluoroethyl)-, (2R,3R,4R)- (9Ci) CAS NO 188905-25-1 is a high-purity, stereochemically defined pyrrolidine derivative of significant interest in advanced organic synthesis. This compound is valued for its unique trifluoroethyl-substituted, polyhydroxylated structure, which serves as a versatile chiral building block. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular scaffolds.

Application

This specialized chiral intermediate enables critical synthetic pathways in several high-value sectors:

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the creation of novel, optically active pesticides and herbicides where specific stereochemistry is crucial for bioactivity.
• Asymmetric Catalysis Ligand Precursor: Its functional groups make it a potential precursor for developing novel chiral ligands and organocatalysts.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tool compounds for studying biological mechanisms and enzyme inhibition.
• Advanced Material Research: Investigated as a monomer or additive for creating specialty polymers with unique properties.

Basic Information

Product Name	3,4-Pyrrolidinediol, 2-(Hydroxymethyl)-1-(2,2,2-Trifluoroethyl)-, (2R,3R,4R)- (9Ci)
CAS No.	188905-25-1
Molecular Formula	C7H12F3NO3
Molecular Weight	215.17 g/mol
Synonyms	(2R,3R,4R)-2-(Hydroxymethyl)-1-(2,2,2-trifluoroethyl)pyrrolidine-3,4-diol; (2R,3R,4R)-1-(2,2,2-Trifluoroethyl)-2-(hydroxymethyl)pyrrolidine-3,4-diol; 1-(2,2,2-Trifluoroethyl)-2-(hydroxymethyl)-3,4-pyrrolidinediol, (2R,3R,4R)-; (2R,3R,4R)-1-Trifluoroethyl-2-hydroxymethyl-3,4-dihydroxypyrrolidine; Chiral Trifluoroethyl Pyrrolidinediol; TFE-Pyrolidinediol Derivative
EINECS	Contact for details

Quality Control

Our production of 3,4-Pyrrolidinediol, 2-(Hydroxymethyl)-1-(2,2,2-Trifluoroethyl)-, (2R,3R,4R)- adheres to stringent quality management protocols. Each batch is characterized and tested to ensure identity, purity, and stereochemical integrity, with typical specifications including chiral purity (enantiomeric excess) and chemical purity by HPLC. Certificates of Analysis (COA) detailing all relevant parameters are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider the use of desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.