Description

Cyclopropanecarboxylic Acid, 1-[(Ethoxycarbonyl)Amino]-2-Fluoro-, Methyl Ester (9Ci) is a high-value fluorinated cyclopropane derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both a fluorinated cyclopropane ring and a protected amino acid ester moiety, makes it indispensable for constructing complex molecules with tailored biological and physical properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials. The CAS number for this product is 188897-48-5.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of fluorinated drug candidates, particularly in protease inhibitor and antiviral research.
• Agrochemical Synthesis: Used to create novel fluorinated pesticides and herbicides, where the cyclopropane and fluorine atoms enhance biological activity and environmental stability.
• Chemical Biology Probe Development: Employed in the design and synthesis of activity-based probes and molecular tags for studying enzyme function and protein interactions.
• Material Science Research: Acts as a precursor for specialty monomers or additives aimed at modifying polymer properties such as thermal stability and surface energy.
• Peptidomimetic Chemistry: The ester-protected amino acid structure makes it valuable for constructing non-natural peptide analogs and constrained scaffolds.
• Catalyst and Ligand Synthesis: Serves as a starting material for developing chiral ligands or organocatalysts containing the rigid cyclopropane backbone.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 1-[(Ethoxycarbonyl)Amino]-2-Fluoro-, Methyl Ester (9Ci)
CAS No.	188897-48-5
Molecular Formula	C8H12FNO4
Molecular Weight	205.18 g/mol
Synonyms	Methyl 1-[(ethoxycarbonyl)amino]-2-fluorocyclopropanecarboxylate; 1-(Ethoxycarbonylamino)-2-fluorocyclopropanecarboxylic Acid Methyl Ester; 2-Fluoro-1-[(ethoxycarbonyl)amino]cyclopropanecarboxylic Acid Methyl Ester; 1-Carbamoyl-2-fluorocyclopropanecarboxylic Acid Methyl Ester, N-Ethoxycarbonyl Derivative; Methyl (1-(((ethoxycarbonyl)amino))-2-fluorocyclopropane)carboxylate; Fluorocyclopropane Amino Acid Ester; CAS 188897-48-5
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 1-[(Ethoxycarbonyl)Amino]-2-Fluoro-, Methyl Ester (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to support cGMP compliance for advanced intermediate production, ensuring traceability and documentation meet the stringent requirements of the pharmaceutical and agrochemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.