Description

3-(Toluene-4-Sulfonyloxy)-Pyrrolidine-1-Carboxylic Acid Benzyl Ester is a high-purity chemical intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the development of complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing pyrrolidine and sulfonate ester motifs.
• Protease Inhibitor Research: Used in the development and scale-up of protease inhibitors and other enzyme-targeting therapeutic agents.
• Peptidomimetic Chemistry: Serves as a protected amino acid derivative for constructing peptidomimetics and modified peptide structures in drug discovery.
• Agrochemical Synthesis: Employed as a building block for creating advanced crop protection agents and herbicides with specific biological activity.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for asymmetric catalysis and metal complexation.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and contract research organizations (CROs/CMOs) requiring high-purity, complex intermediates.

Basic Information

Product Name	3-(Toluene-4-Sulfonyloxy)-Pyrrolidine-1-Carboxylic Acid Benzyl Ester
CAS No.	188846-98-2
Molecular Formula	C19H21NO5S
Molecular Weight	375.44 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-[(4-methylphenyl)sulfonyl]oxy]pyrrolidine; Benzyl 3-[(4-methylphenyl)sulfonyloxy]-1-pyrrolidinecarboxylate; 3-(p-Toluenesulfonyloxy)pyrrolidine-1-carboxylic Acid Benzyl Ester; 1-CBZ-3-(4-Toluenesulfonyloxy)pyrrolidine; N-CBZ-3-(Tosyloxy)pyrrolidine; 1-Benzyloxycarbonyl-3-tosyloxypyrrolidine; Pyrrolidine-1-carboxylic acid, 3-[(4-methylphenyl)sulfonyl]oxy]-, benzyl ester
EINECS	Contact for details

Quality Control

Our 3-(Toluene-4-Sulfonyloxy)-Pyrrolidine-1-Carboxylic Acid Benzyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.