Description

Benzenamine, 4-(3As,4S,6R,6Ar)-6-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-2,2-Dimethyl-4H-1,3-Dioxolo4,5-Cpyrrol-4-Yl- is a sophisticated, high-purity chemical intermediate featuring a protected nucleoside-like structure. This compound is critical for enabling precise synthetic pathways in advanced pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents, particularly nucleoside analogs and complex heterocycles.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of proprietary nucleoside analogs and antiviral/antitumor agents.
• Process Chemistry: Used in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Bioconjugation: Potential use in the development of targeted drug delivery systems and antibody-drug conjugates (ADCs) due to its functionalizable amine group.
• Chemical Biology Probes: Can be utilized to create labeled or modified nucleotides for studying biological mechanisms and enzyme functions.

Basic Information

Product Name	Benzenamine, 4-(3As,4S,6R,6Ar)-6-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-2,2-Dimethyl-4H-1,3-Dioxolo4,5-Cpyrrol-4-Yl-
CAS No.	188745-04-2
Molecular Formula	C21H34N2O3Si
Molecular Weight	390.60 g/mol
Synonyms	4-[(3aR,4S,6R,6aR)-6-[[(1,1-Dimethylethyl)dimethylsilyl]oxymethyl]-2,2-dimethyl-tetrahydro-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl]aniline; 4-[(3aR,4S,6R,6aR)-6-[(tert-Butyldimethylsilyloxy)methyl]-2,2-dimethyl-tetrahydro-4H-1,3-dioxolo[4,5-c]pyrrol-4-yl]benzenamine; TBDMS-protected nucleoside aniline derivative; Aniline nucleoside intermediate; CAS 188745-04-2
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing support. Identity, purity, and impurity profiles are rigorously verified using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.